M-Kast 10 is a prescription medicine used for asthma prevention and for the treatment of allergy symptoms such as sneezing and runny nose. It reduces inflammation in the airways and make breathing easier. M-Kast 10 can be taken with or without food, but take it at the same time to get the most benefit. It is advised to have it 2 hours before exercise if you have exercise-induced asthma. It should be taken as your doctor’s advice. The dose and how often you take it depends on what you are taking it for. Your doctor will decide how much you need to improve your symptoms. Swallow the tablets whole with a drink of water. You should take this medicine for as long as it is prescribed for you. It does not cure sudden breathing problems, so always carry a medicated inhaler with you. It is generally safe medicine with few common side effects include nausea, vomiting, headache, abdominal pain, and diarrhea. If these bother you or appear serious, let your doctor know. There may be ways of reducing or preventing them. Generally, you should avoid alcohol while taking this medicine. Before taking this medicine, you should tell your doctor if you have ever had severe liver problems. Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works. You must inform your doctor about pregnancy or breastfeeding.
Uses of M-Kast 10
- Asthma prevention
- Sneezing and runny nose due to allergies
Side effects of M-Kast 10
How to use M-Kast 10
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. M-Kast 10 may be taken with or without food, but it is better to take it at a fixed time.
How M-Kast 10 works
M-Kast 10 works by blocking the action of leukotriene, a chemical messenger. This reduces inflammation in the airways to prevent asthma and relieve symptoms of allergies.
What if you forget to take M-Kast 10?
If you miss a dose of M-Kast 10, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
- You have been prescribed M-Kast 10 for asthma prevention and for the treatment of allergy symptoms such as sneezing and runny nose.
- It is a relatively safe medicine with very few side effects.
- Take M-Kast 10 2 hours before exercising if you have exercise-induced asthma.
- It does not work right away and should not be used to relieve sudden breathing problems. Use your rescue inhaler to control sudden difficulty in breathing.
- Do not discontinue use without consulting your doctor, even if you feel better.
Asthma, Allergic rhinitis
Oral Chronic asthma Adult: As film-coated tab: 10 mg once daily in the evening. Allergic rhinitis Adult: 10 mg once daily. Prophylaxis of exercise-induced asthma Adult: 10 mg at least 2 hr prior to exercise; do not take additional doses w/in 24 hr. Elderly: No dosage adjustment needed. Hepatic impairment: Mild to moderate: No dosage adjustment needed.
Asthma Prophylaxis and maintenance treatment in patients aged >12 months <12 months: Safety and efficacy not established 12-24 months: 4 mg (granules) PO once daily in evening 2-6 years: 4 mg (chewable tablet or granules) PO once daily in evening 6-15 years: 5 mg (chewable tablet) PO once daily in evening >15 years: 10 mg (conventional tablet) PO once daily in evening Exercise-Induced Bronchospasm Prophylaxis 6-15 years: 5 mg (chewable tablet) PO 2 hours before exercise; do not take additional dose within 24 hours >15 years: 10 mg PO 2 hours before exercise; do not take additional dose within 24 hours If taking drug for another indication, do not take additional dose to prevent EIB Perennial Allergic Rhinitis <6 months: Safety and efficacy not established 6-24 months: 4 mg (granules) PO once daily 2-6 years: 4 mg (chewable tablet or granules) PO once daily 6-15 years: 5 mg (chewable tablet) PO once daily >15 years: 10 mg (conventional tablet) PO once daily Seasonal Allergic Rhinitis <2 years: Safety and efficacy not established 2-6 years: 5 mg (chewable tablet) or 4 mg (granules) PO once daily 6-15 years: 5 mg (chewable tablet) PO once daily >15 years: 10 mg (conventional tablet) PO once daily
Renal impairment: No dosage adjustment needed.
Mode of Action
Montelukast is a selective leukotriene receptor antagonist that blocks the effects of cysteinyl leukotrienes in the airways.
Not for the relief of acute bronchospasm. Not to be used as monotherapy for the prevention of exercise-induced bronchospasm. Patients in whom asthma is precipitated by aspirin or other NSAIDs should continue to avoid aspirin and NSAIDs. Do not abruptly substitute for oral or inhaled corticosteroids. Be alert for any signs of Churg-Strauss syndrome. Pregnancy and lactation. Children <6 mth. Lactation: Unknown whether agent is excreted in breast milk, use with caution
>10% Headache (18.4%; similar to placebo) 1-10% >2% Abdominal pain,Eczema,Influenza,Laryngitis,Pharyngitis,Viral infection,Wheezing,Dental pain,Dizziness,Dyspepsia, Dental pain (2%),Dizziness (2%),Dyspepsia (2%)Elevated liver function tests (2%),Fever (2%),Gastroenteritis (2%),Nasal congestion (2%),Otitis (2%),Rash (2%),Urticaria (2%), >1% Bronchitis,Cough,Sinusitis,Upper respiratory tract infection <1% Allergic granulomatous angiitis (Churg-Strauss syndrome; rare),Cholestatic hepatitis (rare),Aggressive behavior, altered behavior, suicidal thoughts Potentially Fatal: Anaphylaxis, Churg-Strauss syndrome.
Induced hepatic metabolism resulting to decreased plasma concentration w/ potent inducers of cytochrome P450 isoenzymes (e.g. phenobarbital, phenytoin, rifampicin).
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